our technology

SP TECHNOLOGY™

The cornerstone of our serum is our Super Permeability technology, which we refer to as SP-Technology™.

Our cutting edge technology works by taking large, typically unabsorbable bio-molecules and linking them with a natural amino acid chain to create cell-penetrating peptides (CPPs) that enter deep into the skin and interact with receptors in the body. These CPP linked natural biomolecules (that we call SP1-EGF and SP1-FGF1) can then open and activate special channels and transportation systems in skin cell membranes to promote collagen synthesis in the skin.

Originally conceived as a super-permeable absorption drug delivery therapy for wound healing and scar repair, our Bellus scientists quickly realized they could share this revolutionary technology with a broader audience by applying it to rejuvenating skin care products.

Real Results

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This microscopic image shows how effectively fluorescently labelled SP-EGF/FGF1 can penetrate the skin. On the left, liposome bound EGF/FGF1 is limited to the very surface of the skin (shown by the small amount of fluorescence). In contrast, SP1-EGF and SP1-FGF1 has permeated through the epidermis and into the deeper dermis, as evidenced by the large amount of fluorescence.

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This is an actual patient result- as you can see from the ultrasound images, the outer layer of skin (indicated in white) has smoothened after continued use.

Biology of Skin Degeneration and Regeneration

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After the age of 20, collagen fibers in the skin begin to break down and become looser. By the age of 40, the skin has lost about 20% of its collagen. This collagen loss is what causes skin to develop a thin, “crêpy” appearance, wrinkle formation and sagging.

In the image on the right, Bellus Skin Serum has been applied to the skin.  The resulting effect of the deep penetrating SP-enabled growth factors promotes collagen production and increases skin thickness and reduces wrinkles, overall improving the skin’s appearance.

What are Growth Factors?

Growth factors surged in popularity as an ingredient in anti-aging products after Epidermal Growth Factor (EGF) came to the world’s attention when Stanley Cohen and Rita Levi-Montalcini were awarded the 1986 Nobel Prize for its discovery.

Since EGF is a signaling molecule that stimulates tissue growth in the skin, particularly collagen, many cosmetic companies jumped at the opportunity to add it to their skin care products.

However, on their own, EGF and other growth factors have a fundamental issue- they are too large to penetrate the skin when applied topically. One of the most popular delivery methods for EGF/FGF1 delivery are liposomes, which are spherical vesicles that encapsulate large proteins like EGF/FGF1 to increase their absorption into the skin. However, studies have shown that when applied, liposomes burst on the surface of the skin and don’t actually get delivered into the body. 1

It’s only when these growth factors are applied to our SP-Technology™ that the resulting super cell penetrating bio-molecule is able to penetrate the skin’s barrier, bind to growth factor receptor sites in the body and promote collagen synthesis.

When compared to liposomal formulations, SP-Technology is 200 times more absorbable. What does that mean for you? You are getting the best effect from our ingredients since they are getting delivered INTO your body and getting where they need to be, as opposed to bursting on contact with the skin and staying on the surface like liposomes do.

Scientific and Clinical Research 

Numerous clinical studies have shown the active ingredients in Bellus to have:

  1. Superior penetration and absorption deep into the skin2
  2. Increased the thickness of the skin2,5
  3. Improved skin moisture, elasticity and the appearance of wrinkles2,4
  4. Reduction in the appearance of pores3

Our dermatology specialist and clinical scientists conducted multiple clinical studies using Bellus Skin™ on women aged 35 or older, and the resulting data showed that Bellus Skin is effective in improving multiple aspects of aging, including smoothing and reducing the appearance of wrinkles, increasing the density of dermis, softening skin, improving elasticity and moisture, aiding in skin brightening and firming, and improving the look of pores.

1. “Spatially Resolved Two-Color Diffusion Measurements in Human Skin Applied to Transdermal Liposome Penetration”, Journal of Investigative Dermatology, doi: 10.1038/jid.2012.461
2. Korea Institute for Skin and Clinical Sciences. (2014).“Human application test of ‘Bellus Skin GF Recovery Serum’ for the improvement of wrinkles, dermal density, skin drooping, elasticity, and moisturization”.
3.  Derma Pro Skin Reseach Centre, (2015). “A clinical study of skin pore shrinkage (size, number and volume) for bellus skin on human skin.”
4. Internal Study, Wrinkle analysis, (2014).
5. An, J.J., Eum, W.K. (2013). “Protective effects of skin permeable epidermal and fibroblast growth factor against ultraviolet-induced skin damage and human skin wrinkles”. Journal of Cosmetic Dermatology, 12, 287-295.