our science

The Bellus Skin Brand is based on a revolutionary patented technology called Protein Transduction Domain which we refer to as our SP Technology. SP technology (Superior Permeability) is at the core of all Bellus Skin Products.

Collagen and Aging

Epidermal growth factor (EGF) is a signaling molecule that stimulates the growth of epidermal tissues during development and throughout life. Stanley Cohen discovered epidermal growth factor (EGF) during studies of nerve growth factor as a side effect of other experiments. EGF stimulates tissue growth by initiating a variety of cellular mechanisms. This work led to the 1986 Nobel Prize in Physiology or Medicine.


This discovery led a number of cosmetic products to include EGF as an ingredient however Bellus Skin combines both EGF and FGF1 growth factors with our patented SP technology.


Many expensive, yet effective, ingredients are often included in cosmetic products such as EGF or FGF1. However these proteins have difficulty penetrating the skin surface. Bellus Skin SP Technology is a unique clinically proven 100% natural method which enables penetration of these key ingredients to the dermis and epidermis where the effect is profound and long lasting.


Most cosmetic serums and crèmes currently on the market that contain only EGF utilize liposomal formulations. However liposome formulations are limited in their ability to deliver these key ingredients into the skin. SP technology is a scientific breakthrough overcoming the limitations of liposomal formulations. Permeability is increased by up to 200 times when compared to liposomal serums.